VISION

completed

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VISION

The objective of the VISION study was to collect international data regarding major adverse vascular events during non-cardiac surgery.

The increase in elderly patients undergoing surgery, the change in the invasiveness of some surgical interventions, and the limitations of previous research, contribute to uncertainty about the current incidence of major vascular events in patients undergoing noncardiac surgery.

Further, uncertainty exists regarding the optimal clinical risk estimation model for predicting major perioperative vascular events. There is promising but inconclusive evidence that troponin measurements after surgery may allow physicians to avoid missing MIs and predict mortality in the first year after surgery.

Primary endpoint:

Composite of vascular death, nonfatal myocardial infarction, nonfatal cardiac arrest, and nonfatal stroke.

Secondary endpoints:

All the individual components of the composite and each of:

Cardiac revascularization procedures
Congestive heart failure
New clinically important atrial fibrillation
Deep venous thrombosis
Pulmonary embolus
Re-hospitalization for vascular reasons,
Amputation
Bleeding
Pneumonia
Dialysis
Mew diagnosis of diabetes
Sepsis/infection.

Not adjudicated.

VISION MINS Results - Download PDF VISION Mortality Results - Download PDF

Study Type

Observational - Registry

Study Design

Prospective cohort study

NO. of Countries

NO. of Sites

NO. of Participants

40000

Study Period

2007 - 2014

Sponsor

CLARITY McMaster University

Key Team Members

PJ Devereaux

Deputy Director, Senior Scientist

PJ Devereaux

Deputy Director, Senior Scientist

PJ.Devereaux@phri.ca

Devereaux is a cardiologist, perioperative care physician, and clinical epidemiologist. He is the Director of the Division of Perioperative Care at McMaster University and a Deputy Director, Senior Scientist, and Scientific Leader of the Anesthesiology, Perioperative Medicine, and Surgical Research Group at PHRI. He is the Nominated Principal Applicant of the Accelerating Clinical Trials (ACT) Consortium, which is the Pan-Canadian Clinical Trials Consortium funded by the Canadian Institutes of Health Research (CIHR). Additionally, he holds a Tier 1 Canadian Research Chair in Perioperative Medicine.

Devereaux is a full Professor at McMaster University and the President of the Society of Perioperative Research and Care. He has published over 450 peer-reviewed papers and more than 85 book chapters, editorials, and commentaries, including 17 in the New England Journal of Medicine, 13 in the Lancet, and 11 in JAMA. He has an h-index of 115 and has given over 1000 lectures and research presentations in 41 countries. His research program focuses on major vascular complications during and after surgery, and he has led many large international randomized trials and prospective cohort studies on this topic.

Jessica Vincent

Program Director

Jessica Vincent

Program Director

jessica.vincent@phri.ca

Jessica Vincent has more than 15 years’ experience in coordinating and managing large, international clinical trials. As Associate Program Manager, she oversees interventional trials, registries, and observational research studies in the areas of perioperative medicine, cardiac surgery, and digital health.

She holds an Honours Bachelor of Science Degree from Queens University, and a Master of Clinical Epidemiology Degree from the University of Newcastle.