Study Type
Observational
completed
The objective of the TCOM study was to determine the ability of transcutaneous oximetry and transcutaneous carbon dioxide measurements in the legs of patients undergoing below-knee amputation to predict amputation wound healing failure and revision.
Primary endpoints:
- To determine the ability of transcutaneous oximetry and transcutaneous CO2 measurements in the legs of patients undergoing below-knee amputation to predict amputation wound healing failure (defined as the need for amputation revision) and all-cause mortality at 30-days post-amputation.
- To determine an optimum cut-off value for both transcutaneous oximetry and transcutaneous CO2 levels for predicting the occurrence of the first co-primary outcome (revision amputation to higher level or mortality).
Study Design
Observational study
NO. of Countries
1
NO. of Sites
4
NO. of Participants
41
Study Period
2011 - 2014
Sponsor
PHRI
Richard Whitlock
Scientist
Richard Whitlock
Scientist
Richard Whitlock is Associate Chair, Research, and a Professor at the Department of Surgery, McMaster University. He was awarded the inaugural Canada Research Chair in Cardiovascular Surgery in 2020.
As well as being a PHRI Scientist, Richard is a cardiac surgeon and intensive care physician at Hamilton Health Sciences. His clinical focus is on aortic valve intervention and aortic surgery. He is a lead investigator for the CIHR funded studies SIRS, LAAOS III, and TRICS III, which have established a network of more than 120 centres to address important questions in his field.
He has published more than 90 articles in referred journals. Medically qualified at the University of Toronto, Richard received his specialist training in cardiac surgery and critical care medicine at McMaster University. In 2012, he received his PhD in clinical epidemiology.
Jessica Vincent
Program Director
Jessica Vincent
Program Director
Jessica Vincent has more than 15 years’ experience in coordinating and managing large, international clinical trials. As Associate Program Manager, she oversees interventional trials, registries, and observational research studies in the areas of perioperative medicine, cardiac surgery, and digital health.
She holds an Honours Bachelor of Science Degree from Queens University, and a Master of Clinical Epidemiology Degree from the University of Newcastle.
