Study Type
Intervention - Procedure
completed
The STRATUS Pilot study evaluated the use of small-volume (“soft-draw”) blood collection tubes for laboratory testing in reducing anemia and transfusion in intensive care unit patients without significant adverse consequences.
This was a simple, cost-neutral intervention that could improve the quality of patient care and reduce the harms of frequent laboratory testing.
The STRATUS Pilot Study is a prospective observational study (before-after design) to assess the feasibility of implementing a full-scale randomized trial powered for clinical outcomes:
- RBC transfusion
- Incidence and severity of anemia.
Identification of barriers and facilitators of implementation will enhance the conduct of the full-scale trial and facilitate incorporation of the intervention into routine practice.
Primary endpoint: Feasibility
Study Design
Prospective observational
NO. of Countries
1
NO. of Sites
1
NO. of Participants
369
Study Period
2017-2018
Sponsor
PHRI
Deborah Siegal
Associate Senior Scientist
Deborah Siegal
Associate Senior Scientist
Deborah Siegal is an Associate Professor in the Department of Medicine within the Division of Hematology at the University of Ottawa. Her primary research interests include improving patient outcomes after anticoagulant-related bleeding; management of anticoagulants in patients who have acute bleeding complications or require urgent surgery; understanding the factors that influence patient and physician decision-making after anticoagulant-related bleeding; and reducing red blood cell transfusion by minimizing iatrogenic blood loss for laboratory testing.
With expertise in the design and conduct of pragmatic cluster randomized trials, individual patient randomized trials, mixed-methods studies, observational studies and meta-analyses, Deborah Siegal has received peer-reviewed grant support as principal investigator from the Canadian Institutes of Health Research, the American Society of Hematology, CanVECTOR/Heart and Stroke Foundation of Canada, Ontario AFP Innovation Fund, and Hamilton Health Sciences Foundation. She has published 70 peer-reviewed articles including several in high-impact journals such as The New England Journal of Medicine, Circulation, Blood, and Journal of Thrombosis and Haemostasis.
Hamilton Health Sciences
HHS New Investigator Fund
completed
STRATUS
Thrombosis
Using a stepped wedge cluster randomized trial design, the specific aim of the STRATUS study...
