ongoing

The objective of the SCHOLAR-2 study is to evaluate whether is it safe and effective to continue trastuzumab in patients with early stage HER2 positive breast cancer who develop mild, minimally symptomatic or asymptomatic systolic left ventricular dysfunction.

Primary outcome:

The primary efficacy outcome will be the likelihood of completing trastuzumab as planned at its initiation.

The primary safety outcome will be left ventricular ejection fraction.

Study Type

Interventional - Drug

Study Design

Randomized clinical trial phase 2

NO. of Countries

9

NO. of Sites

13

NO. of Participants

130

Study Period

2021 - 2024

Sponsor

PHRI

Juravinski Hospital and Cancer Centre Foundation

Hadley H. Chamberlain Memorial Award

Canadian Cancer Society

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