Study Type
Interventional - Procedure
completed
The objective of the Remote IMPACT study was:
- To determine the effect of remote ischemic preconditioning (RIPC) on surrogate endpoints of cardiac and kidney injury, and;
- To determine what combination of limbs used and number of cycles is most effective.
Primary endpoints:
1) recruitment rate per centre
2) follow-up completeness at 30 days and 6 months after surgery
Secondary endpoints:
1) Peak change in CK-MB in the first 24 hours after surgery
2) Peak change in serum creatinine in the first 4 days after surgery
3) Number of days in the intensive care unit and in hospital after surgery
4) Incidence of death from any cause at 30 days after surgery
5) Incidence of new dialysis required within 30 days after surgery
6) Incidence of documented myocardial infarction at 30 days after surgery
7) Incidence of documented stroke at 30 days after surgery
Study Design
Randomized, double-blind, multicentre, controlled trial of 2 parallel groups
NO. of Countries
4
NO. of Sites
11
NO. of Participants
258
Study Period
2011-2012
Sponsor
PHRI
PJ Devereaux
Deputy Director, Senior Scientist
PJ Devereaux
Deputy Director, Senior Scientist
Devereaux is a cardiologist, perioperative care physician, and clinical epidemiologist. He is the Director of the Division of Perioperative Care at McMaster University and a Deputy Director, Senior Scientist, and Scientific Leader of the Anesthesiology, Perioperative Medicine, and Surgical Research Group at PHRI. He is the Nominated Principal Applicant of the Accelerating Clinical Trials (ACT) Consortium, which is the Pan-Canadian Clinical Trials Consortium funded by the Canadian Institutes of Health Research (CIHR). Additionally, he holds a Tier 1 Canadian Research Chair in Perioperative Medicine.
Devereaux is a full Professor at McMaster University and the President of the Society of Perioperative Research and Care. He has published over 450 peer-reviewed papers and more than 85 book chapters, editorials, and commentaries, including 17 in the New England Journal of Medicine, 13 in the Lancet, and 11 in JAMA. He has an h-index of 115 and has given over 1000 lectures and research presentations in 41 countries. His research program focuses on major vascular complications during and after surgery, and he has led many large international randomized trials and prospective cohort studies on this topic.
Jessica Vincent
Program Director
Jessica Vincent
Program Director
Jessica Vincent has more than 15 years’ experience in coordinating and managing large, international clinical trials. As Associate Program Manager, she oversees interventional trials, registries, and observational research studies in the areas of perioperative medicine, cardiac surgery, and digital health.
She holds an Honours Bachelor of Science Degree from Queens University, and a Master of Clinical Epidemiology Degree from the University of Newcastle.
