Study Type
Observational
Stroke is a major contributor to death and disability globally, and its burden will increase dramatically with ageing populations. The trajectories and determinants of cognitive impairment and functional outcomes after stroke are incompletely understood, particularly in lower income countries.
The PROSPECT platform will prospectively evaluate outcomes after stroke internationally, with integration of interventions and randomized controlled trials (RCTs) to improve cognitive and functional outcomes.
The co-primary outcomes of PROSPECT are cognitive and functional impairment.
The secondary outcomes include: quality of life, depression, fatigue, mortality, recurrent stroke and cardiovascular events, and other adverse events.
Participants will be followed for 5 years post stroke.
The platform will be used for sub-studies including imaging, genetic and biomarker analysis, and for embedded RCTs.
Observational
Prospective global platform
11
13
10,000
2022 - 2033
PHRI
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