Study Type
Interventional - Drug
ongoing
There is clinical equipoise around the optimal choice of antibiotics: the addition of vancomycin to routine prophylaxis may further reduce s-SSI rates and is becoming more popular in particular in the United States. However, no guideline or evidence is currently supporting this approach.
Negative pressure wound dressing technology is showing promising results in several small RCTs in different patient populations as recently summarized in a systematic review, but large, convincing and rigorous studies showing a reduction in surgical site infections are needed.
The objective of PICS Prevena, a randomized 2×2 factorial cluster crossover study, is to determine whether adding vancomycin to cefazolin as well as whether negative-pressure dressing technology (Prevena from KCI-Acelity) can reduce deep sternal surgical site infections following cardiac surgery.
PICS-Prevena Slides - Download PDFStudy Design
Randomized 2x2 factorial cluster crossover
NO. of Countries
1
NO. of Sites
2
NO. of Participants
2228
Study Period
2018-2022
Sponsor
PHRI
Dominik Mertz
Scientist
Dominik Mertz
Scientist
Dominik Mertz is Associate Professor, Division of Infectious Diseases, Department of Medicine, McMaster University, and Medical Director Infection Control at Hamilton Health Sciences. His research interests include the epidemiology and risk factors for resistance and infections by resistant bacteria; prevention of C. difficile infection; infection control and of hospital epidemiology; and antimicrobial stewardship.
He has published more than 60 peer reviewed articles to date, is an associate editor for BMC Infectious Diseases, and serves as the first-named editor for the third edition of the book ‘Evidence-based Infectious Diseases’.
Jessica Vincent
Program Director
Jessica Vincent
Program Director
Jessica Vincent has more than 15 years’ experience in coordinating and managing large, international clinical trials. As Associate Program Manager, she oversees interventional trials, registries, and observational research studies in the areas of perioperative medicine, cardiac surgery, and digital health.
She holds an Honours Bachelor of Science Degree from Queens University, and a Master of Clinical Epidemiology Degree from the University of Newcastle.
Ingrid Copland
Senior Research Coordinator
Ingrid Copland
Senior Research Coordinator
Ingrid Copland has been working in research for McMaster University since 1991. She has been at PHRI for 23 years where she has coordinated large, international, industry and investigator initiated trials. Since 2014 she has been with the perioperative and surgery department coordinating observational, drug and device trials.
KCI-Acelity
Provided the negative pressure wound dressing (Prevena) at no cost. Provided funding for site fees and site coordination.
