Study Type
Interventional - Procedure
completed
The PAIN-STOP pilot study assessed the feasibility of a larger randomized controlled trial evaluating NMDA antagonists and IV steroids, as compared to placebo, in decreasing the chances of clinically significant persistent post-surgical pain (PPSP) after video assisted thoracoscopic surgeries (VATS).
Patients were recruited at two centres over five months, and followed for three months post-surgery.
Primary endpoint:
The proportion of:
1) eligible patients recruited;
2) patients adhering to the study protocol; and
3) patients completing the follow-up at three months.
Along with PHRI’s PJ Devereaux, the co-Principal Investigator of the PAIN-STOP study was Harsha Shanthanna, Associate Professor, Anesthesia, McMaster University.
Study Design
Multi-centre, blinded, randomized controlled trial with 2 X 2 factorial design
NO. of Countries
1
NO. of Sites
1
NO. of Participants
48
Study Period
2017
Sponsor
PHRI
PJ Devereaux
Deputy Director, Senior Scientist
PJ Devereaux
Deputy Director, Senior Scientist
Devereaux is a cardiologist, perioperative care physician, and clinical epidemiologist. He is the Director of the Division of Perioperative Care at McMaster University and a Deputy Director, Senior Scientist, and Scientific Leader of the Anesthesiology, Perioperative Medicine, and Surgical Research Group at PHRI. He is the Nominated Principal Applicant of the Accelerating Clinical Trials (ACT) Consortium, which is the Pan-Canadian Clinical Trials Consortium funded by the Canadian Institutes of Health Research (CIHR). Additionally, he holds a Tier 1 Canadian Research Chair in Perioperative Medicine.
Devereaux is a full Professor at McMaster University and the President of the Society of Perioperative Research and Care. He has published over 450 peer-reviewed papers and more than 85 book chapters, editorials, and commentaries, including 17 in the New England Journal of Medicine, 13 in the Lancet, and 11 in JAMA. He has an h-index of 115 and has given over 1000 lectures and research presentations in 41 countries. His research program focuses on major vascular complications during and after surgery, and he has led many large international randomized trials and prospective cohort studies on this topic.
Jessica Vincent
Program Director
Jessica Vincent
Program Director
Jessica Vincent has more than 15 years’ experience in coordinating and managing large, international clinical trials. As Associate Program Manager, she oversees interventional trials, registries, and observational research studies in the areas of perioperative medicine, cardiac surgery, and digital health.
She holds an Honours Bachelor of Science Degree from Queens University, and a Master of Clinical Epidemiology Degree from the University of Newcastle.
