Study Type
Registry - Observational
ongoing
The Ontario Registry of CHronic Myeloproliferative Neoplasms and Incident Cardiovascular Disease (ORCHID) / Inflammation in Myeloproliferative Philadelphia Chromosome Negative Neoplasms – Relationship with Biomarkers of Disease Activity (IMPACT) is a multi-centre prospective observational registry of patients with chronic myeloproliferative neoplasms (MPN) recruited within one year of diagnosis.
The registry’s goal is to inform the epidemiology and course of MPNs in the contemporary context.
Specifically, as MPN survival improves, and with the advent of treatments that may have cardiovascular adverse effects, there is a need to better understand the evolving epidemiology of MPNs.
The creation of this registry will inform the true incidence of vascular disease in the Tyrosine Kinase Inhibitors (TKI) treated Chronic Myeloid Leukemia (CML), Polycythemia vera (PV), Primary myelofibrosis (PMF) and Essential Thrombocytosis (ET) patient populations.
Study Design
Multi-center prospective
NO. of Countries
1
NO. of Sites
5 target
NO. of Participants
1500 target
Study Period
2016-TBD
Sponsor
PHRI
Darryl Leong
Senior Scientist
Darryl Leong
Senior Scientist
Leong’s clinical interests include cardio-oncology, frailty, multi-morbidity, and echocardiography. He is the Director of the McMaster University and Hamilton Health Sciences Cardio-Oncology Program. Leong graduated from the University of Adelaide Medical School with Deans Listing and Honours for academic excellence in 2000. He completed his cardiology training, Doctor of Philosophy, Master of Public Health, and Master of Biostatistics degrees at the University of Adelaide, Australia. He has completed a fellowship in cardiovascular imaging at the Leiden University Medical Centre, the Netherlands, before relocating to Canada.
Leong is an Associate Professor in the Division of Cardiology, Department of Medicine, at McMaster University and Hamilton Health Sciences. His research is supported by the Canadian Institutes of Health Research, Canadian Cancer Society, and the United States Department of Defense, among others. He has published approximately 200 manuscripts, including leading publications in the Lancet and New England Journal of Medicine as well as top cardiovascular journals. He is a Clinician Scientist of the Heart and Stroke Foundation of Canada and has received the Clive Kearon Mid-Career Award from McMaster University. Additionally, he serves as the Director of the Internal Medicine Resident Research Program and the Cardio-Oncology Program at McMaster University.
Deborah Siegal
Associate Senior Scientist
Deborah Siegal
Associate Senior Scientist
Deborah Siegal is an Associate Professor in the Department of Medicine within the Division of Hematology at the University of Ottawa. Her primary research interests include improving patient outcomes after anticoagulant-related bleeding; management of anticoagulants in patients who have acute bleeding complications or require urgent surgery; understanding the factors that influence patient and physician decision-making after anticoagulant-related bleeding; and reducing red blood cell transfusion by minimizing iatrogenic blood loss for laboratory testing.
With expertise in the design and conduct of pragmatic cluster randomized trials, individual patient randomized trials, mixed-methods studies, observational studies and meta-analyses, Deborah Siegal has received peer-reviewed grant support as principal investigator from the Canadian Institutes of Health Research, the American Society of Hematology, CanVECTOR/Heart and Stroke Foundation of Canada, Ontario AFP Innovation Fund, and Hamilton Health Sciences Foundation. She has published 70 peer-reviewed articles including several in high-impact journals such as The New England Journal of Medicine, Circulation, Blood, and Journal of Thrombosis and Haemostasis.
Sumathy Rangarajan
Program Director
Sumathy Rangarajan
Program Director
Sumathy Rangarajan has been Program Director, Global Health, since 2016, preceded by many years’ service at PHRI in other roles. She oversees the PURE study team, as well as the INVICTUS rheumatic AF treatment trial, the CANPWR pediatric weight management registry, and others.
She holds both a Bachelor of Science Degree and a Master of Science degree from Pune University in India.
Sarah Karampatos
Senior Research Coordinator
Sarah Karampatos
Senior Research Coordinator
Sarah Karampatos has been employed by Population Health Research Institute since 2017, working currently in the Global Health Department on the following cancer survivorship studies: RADICAL PC and ORCHID. She has experience working on large international investigator-initiated studies.
She holds a Masters of Science from McMaster University, Bachelor of Applied Science in Kinesiology from the University of Guelph and a Diploma in Fitness and Health Promotion from Humber College.
