Study Type
Observational - Registry
completed
The objective of the MVP study was to determine:
- If postoperative bridging therapy with full-dose heparin anticoagulation is superior to low-dose heparin bridging therapy in the immediate post-mechanical heart valve implantation period; and
- Whether postoperative bridging therapy with LMWH is superior to UFH bridging therapy in the immediate post-mechanical heart valve implantation period.
MVP was a retrospective chart review of antithrombotic use over 30 days after valve surgery.
Primary endpoint:
To determine whether postoperative bridging therapy with full-dose heparin anticoagulation is superior to low-dose heparin bridging therapy in the immediate post-mechanical heart valve implantation period.
Secondary endpoint:
To determine whether postoperative bridging therapy with LMWH is superior to UFH bridging therapy in the immediate post-mechanical heart valve implantation period.
Study Design
Retrospective chart review
NO. of Countries
1
NO. of Sites
5
NO. of Participants
1777
Study Period
2010 - 2013
Sponsor
PHRI
Richard Whitlock
Scientist
Richard Whitlock
Scientist
Richard Whitlock is Associate Chair, Research, and a Professor at the Department of Surgery, McMaster University. He was awarded the inaugural Canada Research Chair in Cardiovascular Surgery in 2020.
As well as being a PHRI Scientist, Richard is a cardiac surgeon and intensive care physician at Hamilton Health Sciences. His clinical focus is on aortic valve intervention and aortic surgery. He is a lead investigator for the CIHR funded studies SIRS, LAAOS III, and TRICS III, which have established a network of more than 120 centres to address important questions in his field.
He has published more than 90 articles in referred journals. Medically qualified at the University of Toronto, Richard received his specialist training in cardiac surgery and critical care medicine at McMaster University. In 2012, he received his PhD in clinical epidemiology.
Jessica Vincent
Program Director
Jessica Vincent
Program Director
Jessica Vincent has more than 15 years’ experience in coordinating and managing large, international clinical trials. As Associate Program Manager, she oversees interventional trials, registries, and observational research studies in the areas of perioperative medicine, cardiac surgery, and digital health.
She holds an Honours Bachelor of Science Degree from Queens University, and a Master of Clinical Epidemiology Degree from the University of Newcastle.
