Study Type
Interventional - Procedure
The objective of the LAAOS III study was to determine if removing the left atrial appendage can reduce stroke and other complications on top of usual therapy.
Primary outcome was the first occurrence of ischemic stroke* or transient ischemic attack with positive neuroimaging or systemic arterial embolism over the duration of follow-up.
Secondary outcomes over the duration of follow-up (unless otherwise specified) were: all-cause stroke or transient ischemic attack with positive neuroimaging or systemic arterial embolism; composite of ischemic stroke* or transient ischemic attack with positive neuroimaging or systemic arterial embolism or death; ischemic stroke *or transient ischemic attack with positive neuroimaging or systemic arterial embolism occurring more than 30 days after surgery; all cause death.
Safety outcomes were: hospitalization for heart failure; operative safety outcomes; major bleed; myocardial infarction.
* Ischemic stroke is defined as any stroke that is not documented as primary hemorrhagic.
LAAOS III trial - ACC 21 (Download PDF) Surgical AF Ablation Evaluation sub-study- ESC 21 (PDF)Interventional - Procedure
Randomized, blinded, multicenter
27
105
4811
2012 - 2021
PHRI
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