Study Type
Interventional - Procedure
completed
The objective of the LAAOS study was to evaluate surgical left atrial occlusion in patients undergoing cardiac surgery requiring cardiopulmonary bypass and are at elevated risk of atrial fibrillation and stroke.
The study tested feasibility for a large-scale trial aimed at reducing stroke rates in CAD patients at high risk for stroke.
Study Design
Randomized controlled open label
NO. of Countries
1
NO. of Sites
5
NO. of Participants
50
Study Period
2009 - 2011
Sponsor
PHRI
Andre Lamy
Scientist
Andre Lamy
Scientist
Andre Lamy is a cardiac surgeon practicing at the Hamilton Health Sciences since 1996, and Professor in the Department of Surgery, McMaster University. He led the Canadian Institute of Health Research funded CORONARY trial, which evaluated off-pump CABG surgery versus on-pump CABG surgery in 4752 patients. The results were published in the New England Journal of Medicine in 2012 and 2013.
Jessica Vincent
Program Director
Jessica Vincent
Program Director
Jessica Vincent has more than 15 years’ experience in coordinating and managing large, international clinical trials. As Associate Program Manager, she oversees interventional trials, registries, and observational research studies in the areas of perioperative medicine, cardiac surgery, and digital health.
She holds an Honours Bachelor of Science Degree from Queens University, and a Master of Clinical Epidemiology Degree from the University of Newcastle.
ongoing
LAAOS-4
Arrhythmia & Heart Failure
Atrial fibrillation is a common heart condition that happens when the top two chambers of...
ongoing
LeAAPS
Perioperative & Surgery
The purpose of the Left Atrial Appendage Exclusion for Prophylactic Stroke Reduction (LeAAPS) trial is...
completed
LAAOS II
Perioperative & Surgery
Occlusion of the left atrial appendage (LAA) is a potential alternative to anticoagulation for patients...
completed
LAAOS III
Perioperative & Surgery
The objective of the LAAOS III study was to determine if removing the left atrial...
