HOPE-2

completed

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HOPE-2

The objective of the HOPE-2 study was to evaluate whether long term supplementation with folic acid, vitamins B6 and B12 aimed at homocyst(e)ine reduction reduces the rates of major fatal and nonfatal cardiovascular events in patients with established cardiovascular disease and/or diabetes mellitus.

At the time of its publication, the HOPE-2 study was the largest trial of homocysteine lowering B vitamins in CVD prevention.

The trial findings of no benefit for B vitamin supplementation influenced guidelines and patterns of practice worldwide.

Primary endpoint:

Composite of CV death, myocardial infarction and stroke.

Secondary endpoints:

All-cause death, total ischemic events, revascularizations, hospitalization for heart failure, hospitalization for unstable angina, venous thromboembolism, incident cancer and cancer death.

All primary and secondary outcomes were adjudicated (except revascularizations).

Study Type

Interventional - Drug

Study Design

Randomized, double-blind, placebo control, safety/efficacy, parallel group design

NO. of Countries

NO. of Sites

145

NO. of Participants

5542

Study Period

1999-2003

Sponsor

PHRI

Key Team Members

Eva Lonn

Senior Scientist

Eva Lonn

Senior Scientist

Eva.Lonn@phri.ca

Eva Lonn is a Principal Investigator for the Atherosclerosis Imaging and Cardiovascular Prevention programs at PHRI, and a Professor of Medicine in the Division of Cardiology at McMaster University.

She has led several large international trials and was a member of the International Steering Committee of additional landmark cardiovascular prevention trials. She directed the Vascular Research Ultrasound Laboratory at PHRI for more than 20 years. She served for many years on the Canadian Cardiovascular Society Council and Executive Committee. She has received research grants from the Medical Research Council of Canada, the Canadian Institutes of Health Research and the Heart and Stroke Foundation of Canada. She published over 220 peer reviewed articles, and 8 book chapters.

After obtaining her medical degree from the Hebrew University in Jerusalem, Eva Lonn completed clinical training in Internal Medicine, Cardiology and Advanced Imaging at the University of Toronto and research fellowships at the University of Toronto and at McMaster University, where she obtained also a Master of Science degree in Health Research Methodology.

Jackie Bosch

Scientist

Jackie Bosch

Scientist

Jackie.Bosch@phri.ca

Jackie Bosch is the Assistant Dean of the McMaster Occupational Therapy Program and a PHRI Scientist. She has a Bachelor’s degree in Occupational Therapy, a Master’s degree in Clinical Epidemiology and Biostatistics, and a PhD in Rehabilitation Science. She also serves as a Professor in the School of Rehabilitation and has an Adjunct Appointment with the University of Galway College of Medicine, Nursing, and Health Sciences.

Her research focuses on improving functional outcomes in clinical trials, particularly for stroke survivors in low-resource settings, and enhancing clinical trial methods. Bosch has taken on leadership roles in large-scale trials such as HOPE, HOPE-TOO, HOPE-3 (NCT00468923), DREAM (NCT00095654), ORIGIN (NCT00069784), TIPS-3 (NCT01646437), and COMPASS (NCT01776424). She leads the Organized Stroke Care Across Income Levels (OSCAIL) group, which has conducted a proof-of-concept study implementing key aspects of stroke unit care in hospitals within low-resource settings. Currently, the OSCAIL group is working on a community-based study aimed at improving outcomes for stroke survivors in these challenging environments. Bosch is also interested in optimizing how clinical trials are conducted, especially by finding new ways to make the start-up and execution processes more efficient.

Jackie Bosch has published 184 articles and received several awards, including the Lorna Reimer Award for Leadership from the Canadian Occupational Therapy Foundation in 2019 and the Faculty of Health Sciences, McMaster University, Programs Award for Graduate Students in 2014.