Study Type
Observational
completed
Abdominal aortic aneurysms (AAA) are frequent in older population and if left untreated, are at increased risk of life-threatening rupture.
Endovascular aneurysm repair (EVAR) is a minimally-invasive procedure often performed as an alternative to open surgical repair.
EVAR is associated with less postoperative complications, and patients are frequently discharged in the first 24 hours after the intervention. However, EVAR is not associated with a long-term mortality advantage over open repair.
Early cardiac complications occurring after patient discharge that may be undetected might explain the long-term prognostic difference.
The EVAR study was a multicenter prospective cohort study which assessed major cardiovascular complications in patients undergoing EVAR.
Patients will have troponins measured in the first three postoperative days and will be followed for 30 days post-surgery.
Primary endpoint:
For the pilot phase, the primary objective was to determine the feasibility of obtaining at least one troponin (Tn) measurement at day 2 or day 3 after surgery in more than or equal to 75 percent of enrolled patients, whether they are home or in the hospital.
Study Design
Multicentre prospective cohort
NO. of Countries
1
NO. of Sites
2
NO. of Participants
12
Study Period
2017-2019
Sponsor
PHRI
PJ Devereaux
Deputy Director, Senior Scientist
PJ Devereaux
Deputy Director, Senior Scientist
Devereaux is a cardiologist, perioperative care physician, and clinical epidemiologist. He is the Director of the Division of Perioperative Care at McMaster University and a Deputy Director, Senior Scientist, and Scientific Leader of the Anesthesiology, Perioperative Medicine, and Surgical Research Group at PHRI. He is the Nominated Principal Applicant of the Accelerating Clinical Trials (ACT) Consortium, which is the Pan-Canadian Clinical Trials Consortium funded by the Canadian Institutes of Health Research (CIHR). Additionally, he holds a Tier 1 Canadian Research Chair in Perioperative Medicine.
Devereaux is a full Professor at McMaster University and the President of the Society of Perioperative Research and Care. He has published over 450 peer-reviewed papers and more than 85 book chapters, editorials, and commentaries, including 17 in the New England Journal of Medicine, 13 in the Lancet, and 11 in JAMA. He has an h-index of 115 and has given over 1000 lectures and research presentations in 41 countries. His research program focuses on major vascular complications during and after surgery, and he has led many large international randomized trials and prospective cohort studies on this topic.
Jessica Vincent
Program Director
Jessica Vincent
Program Director
Jessica Vincent has more than 15 years’ experience in coordinating and managing large, international clinical trials. As Associate Program Manager, she oversees interventional trials, registries, and observational research studies in the areas of perioperative medicine, cardiac surgery, and digital health.
She holds an Honours Bachelor of Science Degree from Queens University, and a Master of Clinical Epidemiology Degree from the University of Newcastle.
