Study Type
Interventional - Procedure
completed
The objective of the CORONARY study was to compare the risks and benefits of of Off-Pump Coronary artery bypass surgery (CABG) to On-Pump CABG, to determine if one is better than the other. The study was also conducted to see the rate of recruitment with expertise-based randomization across different hospital settings.
The study looked at which of the two techniques reduce major risks associated with CABG.
Primary endpoint:
The occurrence of the composite of total mortality, stroke, nonfatal MI, or new renal failure at 30 days post CABG surgery.
The occurrence of the composite of total mortality, stroke, nonfatal MI, new renal failure, or repeat coronary revascularization (i.e. coronary artery bypass surgery or percutaneous coronary intervention) over five years after randomization.
Secondary endpoint:
The assessment of total costs and resources consumption at 30 days after CABG surgery.
The assessment of total costs and resources consumption at 5 years after CABG surgery. All endpoints are adjudicated.
Study Design
Randomized, treatment, open label, active control, parallel group design.
NO. of Countries
19
NO. of Sites
79
NO. of Participants
4752
Study Period
2006 - 2016
Sponsor
PHRI
Andre Lamy
Scientist
Andre Lamy
Scientist
Andre Lamy is a cardiac surgeon practicing at the Hamilton Health Sciences since 1996, and Professor in the Department of Surgery, McMaster University. He led the Canadian Institute of Health Research funded CORONARY trial, which evaluated off-pump CABG surgery versus on-pump CABG surgery in 4752 patients. The results were published in the New England Journal of Medicine in 2012 and 2013.
Amit Garg
Associate Scientist
Amit Garg
Associate Scientist
Amit Garg is the Associate Dean, Clinical Research, at the Schulich School of Medicine & Dentistry, Western University, has practiced as a staff nephrologist at the London Health Sciences Centre in London, Ontario, Canada since 2003, and is a Professor of Medicine, Epidemiology and Biostatistics at Western University, with a cross-appointment in the Department of Health Research Methods, Evidence, and Impact (HEI) at McMaster University. A past president of the Canadian Society of Nephrology, Amit Garg serves as the current Ontario Lead of the Kidney, Dialysis and Transplantation Program at ICES.
He values his ongoing collaborations with PJ Devereaux and other leading clinician-scientists at PHRI, which has led to several sub-studies funded by the Canadian Institutes of Health Research which examined the effects of perioperative interventions on the risk of acute kidney injury (off-pump cardiopulmonary bypass surgery) in the CORONARY study, and more. A current interest is in pragmatic randomized trials embedded into routine healthcare delivery.
Jessica Vincent
Program Director
Jessica Vincent
Program Director
Jessica Vincent has more than 15 years’ experience in coordinating and managing large, international clinical trials. As Associate Program Manager, she oversees interventional trials, registries, and observational research studies in the areas of perioperative medicine, cardiac surgery, and digital health.
She holds an Honours Bachelor of Science Degree from Queens University, and a Master of Clinical Epidemiology Degree from the University of Newcastle.
