Study Type
Interventional - Drug
completed
Colchicine For Prevention Of Perioperative Atrial Fibrillation In Patients Undergoing Thoracic Surgery (COP-AF) was a multi-center, blinded, pilot randomized controlled pilot study of 100 patients.
The primary objectives were:
1) To determine the feasibility of recruiting patients undergoing thoracic surgery to an RCT of colchicine vs. placebo for the prevention of perioperative atrial fibrillation (AF).
2) To determine the resources required to achieve recruitment, pre-operative randomization, and to conduct a full scale trial; and
3) To assess the compliance with the trial protocol.
Secondary objectives were to determine the incidence of new onset perioperative AF or atrial flutter within the index hospitalization, death, myocardial injury after noncardiac surgery (MINS), stroke or transient ischemic attack (TIA), clinically important bradycardia, clinically important hypotension, life threatening bleeding, major bleeding, sepsis/infection, non infectious diarrhea, as well as on the duration of ICU, step-down and in-hospital stay.
Study Design
Blinded, multicenter pilot RCT
NO. of Countries
1
NO. of Sites
2
NO. of Participants
100
Study Period
2014-2015
Sponsor
PHRI
PJ Devereaux
Deputy Director, Senior Scientist
PJ Devereaux
Deputy Director, Senior Scientist
Devereaux is a cardiologist, perioperative care physician, and clinical epidemiologist. He is the Director of the Division of Perioperative Care at McMaster University and a Deputy Director, Senior Scientist, and Scientific Leader of the Anesthesiology, Perioperative Medicine, and Surgical Research Group at PHRI. He is the Nominated Principal Applicant of the Accelerating Clinical Trials (ACT) Consortium, which is the Pan-Canadian Clinical Trials Consortium funded by the Canadian Institutes of Health Research (CIHR). Additionally, he holds a Tier 1 Canadian Research Chair in Perioperative Medicine.
Devereaux is a full Professor at McMaster University and the President of the Society of Perioperative Research and Care. He has published over 450 peer-reviewed papers and more than 85 book chapters, editorials, and commentaries, including 17 in the New England Journal of Medicine, 13 in the Lancet, and 11 in JAMA. He has an h-index of 115 and has given over 1000 lectures and research presentations in 41 countries. His research program focuses on major vascular complications during and after surgery, and he has led many large international randomized trials and prospective cohort studies on this topic.
Jessica Vincent
Program Director
Jessica Vincent
Program Director
Jessica Vincent has more than 15 years’ experience in coordinating and managing large, international clinical trials. As Associate Program Manager, she oversees interventional trials, registries, and observational research studies in the areas of perioperative medicine, cardiac surgery, and digital health.
She holds an Honours Bachelor of Science Degree from Queens University, and a Master of Clinical Epidemiology Degree from the University of Newcastle.
Physicians' Services Incorporated Foundation (PSI)
Canadian Institutes of Health Research (CIHR)
McMaster University
ongoing
COP-AF
Perioperative & Surgery
Up to 20% of patients undergoing major thoracic surgery develop perioperative atrial fibrillation (POAF), making...
