ongoing

The objective of ASPIRE-AF is to assess the effects of non-vitamin K oral anticoagulants (NOACs) versus no anticoagulation on the co-primary composite outcomes of:

1. non-hemorrhagic stroke and systemic embolism, and
2. vascular mortality, and non-fatal non-hemorrhagic stroke, myocardial infarction, peripheral arterial thrombosis, amputation, and symptomatic venous thromboembolism

over the duration of follow-up in patients with atrial fibrillation (AF) occurring transiently with stress (AFOTS) like non-cardiac surgery and acute illness.

About ASPIRE-AF
Study Type

Inteventional - Drug

Study Design

Prospective, randomized, open-label clinical trial with blinded outcome assessment

NO. of Countries

20

NO. of Sites

130

NO. of Participants

2270

Study Period

2019 - 2030

Sponsor

PHRI

Canadian Institutes of Health Research

Canadian Stroke Prevention Intervention Network (C-SPIN)

Hamilton Health Sciences

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