Shamir Mehta
A PHRI trial has changed how the global medical field treats a heart attack involving a completely blocked coronary artery.
The results of the COMPLETE trial have received the highest class (1) of recommendation and highest level (A) of evidence by the triad of governing bodies – the American College of Cardiology (ACC), the American Heart Association (AHA), and the Society for Cardiovascular Angiography and Interventions (SCAI).
An 1A recommendation is rare in any type of clinical practice guidelines, so this is a big accomplishment for PHRI Senior Scientist Shamir Mehta and his international collaborators on the Complete vs Culprit-only Revascularization Strategies to Treat Multi-vessel Disease after Primary PCI for STEMI (COMPLETE) randomized controlled trial that ran 2010-2019.
COMPLETE results were published in the New England Journal of Medicine in September 2019, while simultaneously presented by Dr. Mehta at the European Cardiology Congress (ESC 2019). Within a few months, COMPLETE-TIMING and COMPLETE-OCT sub-studies were presented at TCT and AHA 2019 conferences respectively.
The aim of the 2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization [PDF] is to “replace the 2011 coronary artery bypass graft surgery, and the 2011 and 2015 percutaneous coronary intervention guidelines, providing a patient-centric approach to guide clinicians in the treatment of patients with significant coronary artery disease undergoing coronary revascularization as well as the supporting documentation to encourage their use.”
In the planning stage, the COMPLETE-2 trial, also led by Dr. Mehta, will investigate physiology-guided versus angiography-guided complete revascularization to treat multivessel disease after early percutaneous coronary intervention for the type of heart attack known as STEMI.
In 2021, Dr. Mehta received a $2-million endowed chair that will allow him to focus even more on his pioneering research into this vital area to treat serious heart attacks and prevent recurrent attacks.
Watch the video about the inaugural Douglas Holder/PHRI Chair in Interventional Cardiology to learn more.
Congratulations to Dr. Mehta and his international team on making an impact on lives around the world with their groundbreaking discoveries in cardiac procedures!
